1314-1315 / 2437
• Bruton tyrosine kinase (BTK) inhibitor
BTK links the B-cell antigen receptor (BCR) and Toll-like
receptors with the NF-κB pathway
• Monotreatment or in combination with other drugs
• Increased aspergillosis as a particular side effect
• Retrospective series of 13 patients with recurrent PCNSL
Overall response rate: 50%
Chamoun et al., Neurology 2017
Novel agents: Ibrutinib