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Medulloblastoma
Arguments
against
additional Chemotherapy
The additional adjuvant CT is
not practible
with
Standard protokoll („Packer“) for „standard risk „ Patients .
Therefore a dose reduction in the spinal axis
(von 36 auf 23.4 Gy) should be taken into account. Data Padovani ?
Additional adjuvant CT increases Toxicity without improving
the prognosis (Greenberg et al., 2001).
All hyperfractionated RTs for „standard risk“ patients
result in identical OS with only minor neurocognitive dysfunction.
(M-SFOP 98, Mumbai) im Vergleich
mit reduz. kon. RT mit Chx.. eine zusätzl. Chx.ist daher verzichtbar.
Medulloblastom in Adults