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24/10/2017

Toxicity:

5 patients with grade 3 unilateral optic

neuropathy

2 patients with grade 4 bilateral optic

neuropathy

13 patients with Grade 3 temporal lobe

necrosis

1 with cerebellar necrosis

1 grade 4 spinal cord necrosis

3 patients with grade 3 unilateral hearing loss.