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0

6

12

18

24

Time (months)

100

80

60

40

20

0

Survival

(%)

WBRT + SRS

WBRT alone

WBRT + SRS

WBRT alone

100

80

60

40

20

Local progression free survival

(%)

WBRT

WBRT alone

local control

survival

WBRT +/- radiosurgery for brain metastases

WBRT whole brain RT

SRS

stereotactic

radiosurgery

RTOG 9508

Andrews

et al 2004, Lancet; 363: 1665–72