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PHYSIOLOGICAL IMAGING
PERFUSION MRI
• Provides hemodynamic informations and estimates the cerebral blood volume that reflect
the underlying microvasculature, marker of angiogenesis
• Exploit signal changes that accompany the passage of a paramagnetic contrast agent
thorugh the cerebrovascular system
• Useful if patients receive antiangiogenetic cancer therapies to monitor its efficacy
• Maps of cerebral blood volume can serve as an additional targets for brain tumour biopsies
• May help in differentiating radiation necrosis and recurrent tumour
• May help differentiating tumor infiltrated edema (high grade gliomas) and vasogenic edema
(in case of metastases)
PITFALL:
NO CORRELATION
WITH TUMOR GRADING
Di Stefano et al. 2014