398-399 / 2437
Author/
study
Pat. ”low quality” ”high quality” Survival
Significance
Packer et
al., 1991
108 RT 1975 -82
n=67
RT 1983-89
n=41
49% vs.82% 5-y PFS Significant
P=0.004
Graben
bauer et al.,
1996
40 RT before 1980 RT after 1980 5-y overall survival
64% versus 80%
Significant
p=0.02
Miralbell, et
al.1997
77 36 inadequate
„helmet-
technique“
41 adequate
„helmet-
technique“
5-y PFS
94 % versus 72 %
Significant
p=0.016
Carrie et
al., 1999
169 Min. viol. :67
(40%)
Maj. Viol. :53
(31%),
Of these :
36 one maj.
Viol.
11 two maj. Viol.
6 three maj.Viol.
49 (29%)
3 y. relapse rate
33% : all patients
23 % : corr.
Treatment
17% : one maj. Viol.
67% : two maj. Viol.
78% : three maj.
Viol.
Significant.
P=0.04
Packer et
al., 1999
63 Violations : 20
No viol.: 43 5-y PFS
81% vs. 70%
Not signif.
P=0.42
Medulloblastoma - Quality of Radiotherapy