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Radiobiology of RT/SRS/FSRT
•
The goal of any medical intervention is to reach the
highest role of
clinical success
in terms of desired effect
with the minimum rate of side effects
treatment related
•
Historically radiation was delivered considering a variable
safety margin to include
microscopic tumor infiltration
in
normal tissue
•
The relationship between time of radiation, dose and
number of fractions, to influence the biological effect is
based on 4Rs of ionizing radiation
A. Santacroce, et al., biomed research
International, 2013