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Systemic treatment of brain mets
There is no specific chemotherapy (or any specific medical
treatment) for brain mets
Most brain mets derive from chemo-resistant primary
tumors
The best chemotherapy for the primary tumor is also the
best choice for brain metastases
Brain mets have (probably) no blood-brain barrier (BBB)
Drugs that cross the BBB may be helpful for the prevention
of metastasis to the brain and/or for the treatment of
„micrometastases“
Basic considerations