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RT RCT-
summary
•
Radiotherapy is effective at a dose of 45 to 54 Gy
•
Higher dose could be dangerous (late toxicity seen more often in the
HD arm of the NCCTG trial)
•
Early postoperative radiotherapy determined significant improvement
in progression free survival from 3.4 to 5.3 years in the EORTC 22845
trial
•
Deferring radiotherapy did not impact adversely on overall survival,
but
the effect on PFS and Freedom from seizure may substancially
impact on quality of life
•
Those trials were carried out between the 80s and the 90s, with quite
simple radiotherapy techniques also including Cobalt