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Treatment

IDH mutation status

High risk Low

Grade Glioma

IDHwt

Combined

treatment

modality,

novel

treatment

approaches

IDHmt

1p/19q

codel

Single modality

treatment: TMZ

alone or RT

alone

1p/19q

noncodel

Combined

treatment

with RT +/-

CHX

Treatment algorithm based on molecular

marker

Courtesy of B. Baumert