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Risk of esophageal cancer following breast cancer

according to radiotherapy dose

Design

Nested case–control study of esophageal cancer among 289 748 ≥5-year

survivors of female breast cancer from five population-based cancer registries

(252 cases, 488 individually matched controls), with individualized radiation

dosimetry and information abstracted from medical records.

OR = exp(∑

j

α

j

x

j

)

[1 + βz]

x

j

: clinical factors

z: radiation dose in Gy

β: excess OR per Gy