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Grading according CTCAEv4.0
Simple and relatively straightforward endpoints
EXAMPLE: Anemia
Grading
Descriptions
Grade 1
Hemoglobin (Hgb) <LLN - 10.0 g/dL; <LLN - 6.2 mmol/L; <LLN - 100 g/L
Grade 2
Hgb <10.0 - 8.0 g/dL; <6.2 - 4.9 mmol/L; <100 - 80g/L
Grade 3
Hgb <8.0 g/dL; <4.9 mmol/L; <80 g/L; transfusion indicated
Grade 4
Life-threatening consequences; urgent intervention indicated
Grade 5
Death