262-263 / 1676
Example
0%
20%
40%
60%
80%
100%
CHART
Conventional
No mucositis
Patchy mucositis
Confluent mucositis
Acute toxicity
Late toxicity
CHART results in significant increase in
acute mucosal reactions but protects
against late mucosal reactions:
Acute toxicity is NO surrogate marker for
late mucosal reactions
Toxicity
CHART
Observed/expected
Conventional
Observed/expected
Superficial and
deep mucosal
ulceration
0.64
1.53
Dische et al. Radiotherapy Oncology 1997; 44: 123-136