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Prognostic factor:
–
Factor that is associated with outcome
•
Predictive factor:
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Factor that predicts whether certain treatment approach
is beneficial
•
Obtained from RCT’s (hypothesis generating: power!)
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Preferably obtained from meta-analysis
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Factor that predicts whether certain prognostic factor is
associated with endpoint
•
May negatively affect power and required number of
patients in prognostic factor studies
Prognostic vs. predictive factor