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Enrolment bracket
Number of
patients
Number with
major adverse
impact
Percent
1-4 (26 centers)
57
17
29.8%
5-9 (22 centers)
130
28
21.5%
10-19 (22 centers)
279
33
11.8%
> 20 (11 centers)
352
19
5.4%
Better few centres with many patients, than many centres with few
patients
Risks of non-compliance
Peters, et al. J Clin Oncol 2010; 28: 2996-3001