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Heterogeneity
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The results loose credibility
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Different effect sizes in different trials
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Different patient cohorts?
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Different treatment efficacy?
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Quality of data
- How often is the TSH measured?
- In Hodgkin patients?
- In H&NSCC patients?
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An opportunity to learn
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Which patients benefit?
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Which is the better treatment?
The assumption behind a meta-analysis is that
1) The interventio i t same
2) The effect size is the same in different cohorts