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Prospective
data registration
IMPT
dose
optimisation
Multivariable
NTCP model
IMPT protons
IMRT photons
Model-based
validation
IMRT
dose
optimisation
Most relevant dose
Volume factors
∆NTCP-
profile
Model-based approach
Rapid Learning Health Care (RLHC) system
‘Validation train’ approach:
1.
No change
2.
Recalibration intercept
3.
Recalibration intercept and slope
4.
Refit