Quantitative Methods 2017

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NTCP-models

Problems of available literature

1.

Retrospective assessment

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Underestimation

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Interpretation of available data

2.

Lack of multivariable models

3.

NTCP-models based on RCT’s

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Highly selected (only: 1-5%)

4.

Evolution over time

5.

Uniformity OAR definition