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Prospective
data registration
IMPT
Multivariable
TCP model
IMPT protons
IMRT photons
Model-based
validation TCP
IMRT
TCP-model
improvem nt
Selection based
on ∆NTCP-
profile
‘Validation train’ approach:
1.
No change
2.
Recalibration intercept
3.
Recalibration intercept and slope
4.
Refit
Model-based approach
Rapid Learning Health Care (RLHC) system