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Literature: Lung / heart
In summary
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5 papers
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5 different models for radiation pneumonitis
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4 include heart dose, but in each a different manner!
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Lots of discussion and interpretation on their differences
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What really happened: Single-institution model development, no validation
What is needed: Pooling of data in large databases to
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capture the effect of differences between institutes
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reduce model selection uncertainty
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facilitate model selection using validation techniques
Direct validation of the biological findings!!
December 8, 2015