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Extreme breast hypofractionation –
preoperative single-dose PBI
Ongoing Phase II studies
1. Duke University 1x21 Gy
•
in prone position
•
breast-conserving surgery at 6 weeks after RT
2. UMC Utrecht 1x20 / 15 Gy
•
in supine position
•
breast-conserving surgery at 6 months after RT
•
Primary endpoint: pathological complete response
Horton IJROBP 2015, Charaghvandi RO 2015