Target Volume Determination 2016

883 / 1031

• 11C-methionine
– marker of proteine synthesis (essential AA)
– based on increased cellular proliferation in tumour cells
showing increased amino acid transport
– > brain tumors
• 18F-MISO / 18F-HX4 / 18F-AZA
– nitroimidazoles, markers of tumor cell hypoxia
– based on reduction of marker and accumulation under
hypoxic conditions
– > head-and-neck, (N)SCLC
GV