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• Dose rate ≥ 0.5 Gy/h

• Treated surface ≥ 8 cm

2

or > 12 cm

2

• Catheter spacing ≥ 15 mm

• Total dose of exclusive brachytherapy ≥ 65 Gy

• Total dose of EBI + brachytherapy > 80 Gy

Pernot et al :

Radiother Oncol 1995;35:177–185

IJROBP 1994;29:973–679

Mazeron et al :

IJROBP 1990;18:1299–1306

IJROBP 1990;19:281–285

Radiother Oncol 1991 ;21:38–47

• Lead protection of the mandible

Mobile Tongue

Prognostic factors for late complications