899 / 1609
Local
Control
Surv. w/o
colostomy
Disease spec.
Survival
Survival
EORTC
RT only
Radio-
chemo
55 %
p = 0,02
68 %
40 %
p = 0,002
72 %
55 %
NS
57 %
UKCCCR
RT only
Radio-
chemo
39 %
p <0,0001
61 %
61 %
p = 0,02
72 %
58 %
p = 0,25
65 %
Ref. : Bartelink : J Clin Oncol 1997;5:2040–2049
: UKCCCR : Lancet 1996;348:1049–1054
Which patients benefit from
irradiation and concomitant chemotherapy?