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Still a role for watch & wait in asymptomatic pts

Wait for indication of treatment

Combined R-chemo standard; R-CHOP or R-Benda most often used

R-Benda with longer PFS and lower toxicity

No clear superiority of R-CHOP over R-CVP

R-chemo plus R-maintenance current best option in follicular,

particularly in relapsed disease

High-dose chemo and ASCT in r&r or transformed pts

Perspectives: Bortezomib, Lenalidomide, Obinutuzumab (GA101),

Ofatumumab, Temsirolimus, Ibrutinib, Idelalisib, ABT-199

Standard of care in pts with indolent lymphomas