1405 / 1498
•
Dosoretz et al.
treated 30 PBLs with RT alone
5 year-DFS: 53%; OS:63% Cumulative incidence of local recurrence: 14%
No local failures if dose up to 50 Gy
•
Fairbanks et al.
reported on 63 Stage IE PBLs
50 pts received RT alone, 10 CMT, 2 CT alone, 1 surgery alone
Univariate analysis:
improved 5-year DFS with CMT vs RT alone (90% vs
57%)
Doses over 40 Gy improved OS
•
Bacci et al.
30 pts with localized PBL with 10 yrs follow-up
26 pts CT with anthracycline-chemo: 3 systemic relapses
4 RT only (30-45 Gy whole bone; 10-15 Gy boost): 1 local relapse
DFS 88 % at 87 months mean follow-up
Excellent cure rates with the addition of CT to RT
Treatment: CMT as standard approach