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MHC

T Cell Receptor

Antigen

B7.1

/

CD80

B7.2

/

CD86

CD28

CTLA-4

/

CD152

B7DC

/

PDL2

/ CD273

B7H1

/

PD-L1

/ CD274

B7-H4

/ B7X / B7S1 / VTCN1

GITRL

/ AITRL / TNFSF18

B7-H3

/ CD276

OX40L

/ gp34 / CD252

CD137L

/

4-1BBL

/ TNFSF9

PD-1

/

PDCD1

/

CD279

?

?

GITR

/ AITR / TNFRSF18

?

OX40

/ ACT-135 / TNFRSF4 / CD134

CD137

/

4-1BB

/ ILA / TNFRSF9

T Cell

Antigen

Presenting Cell

ICOSL

/ B7H2 / GL50 / B7RP1 / CD275

ICOS

/ CD278/ AILIM / CRP-1

LAG-3

/ CD223

Understanding T- cell Immune Check-Points in the Tumour

Microenvironment and Reversing Immunosuppression

Inhibitory receptors

Activatory receptors