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Pathology of cHL: rare malignant
Reed-Sternberg cells within an extensive
inflammatory/immune cell infiltrate.
Genetic analyses: frequent 9p24.1
amplification with upregulation of
PD-1 ligands and JAK2.
Hypothesis: cHL may have a gene- tically
driven dependence on PD-1.
PD-1 Blockade in HL
Background
Juszczynski et al, PNAS 2007; 104: 13134
Green et al, Blood 2010; 116: 3268; Chen et al. Clin Cancer Res 2013; 19:3462