255 / 1498
•
Mediastinal radiotherapy increases
mortality
of CVD, esp. coronary artery
disease
(Boivin, Cancer 1992; 69:1241; Hancock, JAMA 1993; 270:1949; Swerdlow
JNCI 2007; 99:206; Aleman JCO 2003; 21:3431)
•
Fewer studies examined CVD
morbidity
(Hull JAMA 2003; 290:2831; Aleman, Blood 2007; 109:1878; Glanzmann, Rad
Oncol 1998; 46:51)
•
Increased mortality for > 25yrs
•
Also increased risk for valvular disease
(Aleman, Blood 2007; Hull, JAMA
2003)