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Literature cardiovascular disease after HL, II
•
Radiation dose-response? Only assessed in childhood cancer, childhood HL and
breast cancer
•
Schellong PBC 2010 (childhood HL): Effect of prescribed mediastinal RT dose on
risk (very small numbers per dose category)
•
Mulrooney BMJ 2009 (CCS): increased risk for prescribed doses ≥ 15 Gy
•
Dose to heart or cardiac substructures assessed in only two studies
(Darby NEJM
2013; Tukenova JCO 2010)
•
Tukenova JCO 2010 (CCS): for all CVDs combined (n=32) association with
average radiation dose to heart