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Results from the trials

Early stage disease

Chemotherapy improves the cure rate over radiation alone (EORTC-H7)

Sub-optimal chemotherapy (EBVP) needs RT for best results (EORTC-H9)

Reducing size of the radiation field is safe

Reducing the radiation dose is possible for good prognosis disease, or after

adequate chemotherapy

Omitting radiotherapy altogether may be possible for some patients: can we

predict who they are?