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HL became curable with the introduction of multi-agent chemo

ABVD associated with 65-70% PFS and 75-80% OS @5yrs

B.esc gave 15-20% better PFS and 10-15% better OS than ABVD

Treatment-related mortality and 2

nd

npl of BEACOPP similar to ABVD;

more hematotox and infertility

6xB.esc: tumour control 89%, OS 95%; PET-guided RT (HD15)

B.esc not to be used in pts >40 yrs and poor performance

Ongoing trials evaluate PET-guided strategies and combining BV with

ABVD (enhance efficacy) BEACOPP (reduce toxicity)

Advanced stage HL

Summary