565 / 1498
0
10
20
30
40
Conventionnal
low dose
Radiation dose (Gy)
Clinical study on 109 patients (2003) -
(2 X 2 Gy) in indolent Lymphoma
- Local response rate 92 %
- Complete response 61 %
- Very rapid responses, No side effects
(Haas et al. JCO. 2003)
(Knoops L et al Blood 2007)
Radiation sensitivity of indolent lymphomas
'immune signature‘ genes, activated by RT including
macrophages (e.g., CD68, TLR4),
TH1 immune response (e.g., IL18, CXCL9, 10, 11),
clearance of apoptotic cells