59 / 1498
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Mustargen as antitumor agent evolved from observed effects of mustard gas
in ww1
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Depression of the hematopoietic system was observed in survivors
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Nitrogen mustard is an alkylating agent
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First non-hormonal chemical demonstrating clear clinical antitumor
activity
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Studies published in 1946 demonstrated regression especially of lymphomas
•
Nitrogen mustard (mechlorethamine, mustargen) and other less toxic and
more clinically effective derivatives were developed
Mustargen and the history of alkylating agents
Colvin OM. History of the alkylating agents; 19(3):363-371.