596 / 1498
indolent lymphoma: an open-label, phase 2 trial
Fowler et al
Lancet Oncol. 2014 Nov;15(12):15.
Can cytotoxic chemotherapy be avoided ?
Lenalidomide 20mg Days 1-21 Cycles 1-6*
Months
1 2 3 4 5 6
Rituximab 375mg/M
2
Day 1 of Cycles 1-6
If clinical benefit, can
proceed to 12 cycles
•
Planned Enrollment
•
N= 50 Follicular lymphoma (grade I/II)
•
N=30 Small lymphocytic lymphoma
•
N=30 Marginal zone lymphoma
R= RESTAGING
R
Lenalidomide 20mg Days 1-21 Cycles 7-12*
Rituximab 375mg/M
2
Day 1 of Cycles 7-12
R
R
R
7 8 9 10 11 12
*SLL patients: Dose escalation of lenalidomide
starting with cycle 1: (10mg, 15mg, 20mg)