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PET-CT BASED RESPONSE
CT-BASED RESPONSE
Complete Metabolic Response (CMR)
Complete Radiologic Response (CR)
LNs & EN
sites
Score
1, 2, or (3)
*
±
a residual mass
Target nodes/nodal masses must regress
to
< 1.5 cm
in LDi.
No EN sites.
Partial Metabolic Response (PMR)
Partial Remission (PR)
LNs & EN
sites
Score
4,5
** with
reduced
uptake
compared with baseline
> 50%
decrease in SPD of up to 6 target
measureable nodes and EN sites
No Metabolic Response (NMR)
Stable disease (SD)
LNs & EN
sites
Score
4,5
+
no significant change
in
uptake from baseline
.
< 50%
decrease from baseline in SPD of up
to 6 dominant, measurable nodes & EN
sites;
Progressive Metabolic Dis (PMD)
Progressive disease (PD)
LNs & EN
sites
Score
4,5
+ an
increase
in uptake
from baseline
&/or
New
FDG-avid foci consistent with
lymphoma
PPD Progression:
An individual node must be abnormal with:
•
LDi > 1.5 cm &
•
Increase by ≥ 50% from PPD nadir AND
An increase in LDi or SDi from nadir
0.5 cm for lesions < 2 cm
1.0 cm for lesions > 2 cm
Spleen must increase by > 50% of previous increase