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Implications

Salvage RT is an

option

in

localized

refractory / relapsed

DLBCL:

Definitive salvage in transplant ineligible pts

Additional treatment for transplant eligible pts

Use of RT

in salvage chemotherapy / transplant

trials

should

be controlled for.

Remaining questions:

Can

Dose escalation

improve outcome of Refractory or Resistant

disease?

Does higher

tumor volume

require higher dose?

What is the

size

of ref/rel

population

that could be salvaged by RT?