1052 / 1708
Current COG Guidelines
Stage
Chemotherapy
Radiotherapy
Stage I, FH, age < 2 years with tumor and
kidney weight < 550 grams
None
None
Stage I and II, FH with no LOH 1p and 16q
VCR and AMD
(Regimen EE4A)
None
Stage I and II, FH with LOH at 1p and 16q
VCR, AMD and DOX
(regimen DD4A)
None
Stage III, FH with no LOH at 1p and 16q
VCR, AMD and DOX
(Regimen DD4A)
Abdominal/Flank RT
Stage III, FH with LOH at 1p and 16q
VCR, AMD, DOX, CPM,
VP16 (Regimen M)
Abdominal/Flank RT
Stage IV, FH with no LOH at 1p and 16q
VCR, AMD and DOX
(Regimen DD4A)
Abdominal/Flank RT if Local
Stage III
Lung XRT if Lung Mets not
CR
Stage IV, FH with LOH at 1p and 16q
VCR, AMD, DOX, CPM,
VP-16 (Regimen M)
Abdominal/Flank RT if Local
Stage III
Lung XRT if Lung Mets