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Current COG Guidelines
Stage
Chemotherapy
Radiotherapy
Stage I-III, FA
Stage I, DA
VCR, AMD and DOX
(Regimen DD4A)
Abdominal/Flank RT
Stage IV, FA
Stage II-IV, DA
(with no measurable
disease)
Stage IV, CCSK
Stage I-IV, RTK
VCR,AMD, DOX, CPM,
VP16, CARBO
(Regimen UH-1)
Abdominal/Flank RT
Lung RT if lung mets
Stage IV, DA (with
measurable disease)
VCR, AMD, DOX, CPM,
VP16, CARBO,
IRINOTECAN
Abdominal/Flank RT
Lung RT if lung mets
Stage I-III CCSK
VCR, AMD, DOX, CPM,
VP16
(Regimen I)
Abdominal/Flank RT except
Stage I CCSK