Second malignancies :Adulte and child
•
Probably
the dose response is linear
with no
downturn in risk when the dose increase even after 60
gy except for thyroid with down turn after 20gy ;
(Berrington )
•
After high dose exposure (> 5gy ) Excess of risk is 10
times lower than risk after low dose exposure (2 gy))
for Breast :role of fractionation and perhaps dose to
the ovary done for infradiaphragmatique Rt in HD
before 2000