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age and subgroup interaction and a restricted cubic spline function with three knots for age to allow for a nonlinear relationship. All
P
values reported are two-sided. All statistical analyses were performed in the R statistical environment (v3.1.2), using R packages of
survival (v2.37-7), rms (4.3-1), Coxphf (v1.1), and ggplot2 (v1.0.0).
EPN_PFA
EPN_PFB
0
5
10
15
20
Subgroup
Age (years)
St Jude’s Cohort
B
EPN_PFA
EPN_PFB
0
10
20
30
40
50
Subgroup
Age (years)
GENE Cohort
A
EPN_PFA
EPN_PFB
0
10
20
30
40
50
60
Subgroup
Age (years)
Burdenko Cohort
D
C
EPN_PFA
EPN_PFB
0
10
20
30
40
50
60
Subgroup
Age (years)
Patients (%)
CERN Cohort
E
0%
20%
40%
60%
80%
100%
0–4
5–9
10–17
18+
EPN_PFA
EPN_PFB
Age Group (years)
Fig A1.
(A-D) Boxplots of the age distribution of EPN_PFA and EPN_PFB, where boxes represent median and interquartile range and whiskers represent 95% CIs. (E)
Proportion of patients with EPN_PFA and EPN_PFB in each age group. CERN, Collaborative Ependymoma Research Network; GENE, Global Ependymoma Network of
Excellence.
www.jco.org© 2016 by American Society of Clinical Oncology
Treatment of Posterior Fossa Ependymoma Subgroups
from 139.18.224.1
Information downloaded from
jco.ascopubs.organd provided by at UNIVERSITAETSKLINIKUM LEIPZIG on June 20, 2016
Copyright © 2016 American S ciety of Clinical Oncology. All rights reserved.