1613 / 1708
Clinical Investigation
Neuropsychological Outcome of Children Treated
for Standard Risk Medulloblastoma in the PNET4
European Randomized Controlled Trial of
Hyperfractionated Versus Standard Radiation
Therapy and Maintenance Chemotherapy
Hugo Caˆmara-Costa, PhD,
*
Anika Resch, MSc,
y
Virginie Kieffer, MSc,
z
Cle´mence Lalande, MSc,
x
Geraldina Poggi, MD,
k
Colin Kennedy, MBBS, MD,
{
Kim Bull, PhD,
{
Gabriele Calaminus, MD,
#
Jacques Grill, MD, PhD,
x
Franc¸ois Doz, MD,
**
Stefan Rutkowski, MD,
y
Maura Massimino, MD,
yy
Rolf-Dieter Kortmann, MD,
zz
Birgitta Lannering, MD,
xx
Georges Dellatolas, MD, PhD,
*
and Mathilde Chevignard, MD, PhD
kk
, on behalf of the Quality of
Survival Working Group of the Brain Tumour Group of SIOP-Europe
*National Institute of Health and Medical Research, INSERM U1178, Paris, France;
y
University
Medical Center Hamburg-Eppendorf, Hamburg, Germany;
z
Saint Maurice Hospitals, Saint Maurice,
France;
x
Institut Gustave Roussy, Villejuif, France;
k
Scientific Institute, IRCCS Eugenio Medea,
Bosisio Parini, Lecco, Italy;
{
University of Southampton, Faculty of Medicine, Southampton, United
Kingdom;
#
Paediatric Oncology, University of Muenster, Muenster, Germany; **Institut Curie and
University Paris Descartes, Sorbonne Paris Cite´, Paris, France;
yy
Fondazione IRCCS, Istituto Nazionale
Tumori, Milan, Italy;
zz
Department of Radiation Therapy, University of Leipzig, Leipzig, Germany;
xx
Paediatric Oncology, University of Gothenburg, Gothenburg, Sweden; and
kk
Rehabilitation
Department for Children With Acquired Neurological Injury, Saint Maurice Hospitals, Saint Maurice,
and Sorbonne Universite´s, UPMC Universite´s Paris, INSERM CNRS, Paris, France
Received Feb 11, 2015, and in revised form Apr 4, 2015. Accepted for publication Apr 10, 2015.
Reprint requests to: Hugo Caˆmara-Costa, PhD, INSERM U1178
(Secteur Jaune, porte 45, 1er e´tage), 16 ave Paul Vaillant Couturier, 94807
Villejuif, France. Tel: 33 01 45 59 52 48; E-mail:
hugocamaracosta@ gmail.comThis manuscript corresponds to an original study performed by the
authors. Preliminary findings were presented at the 16th International
Symposium on Paediatric Neuro-Oncology, Singapore, June 2014.
This study was supported by the Brain Tumour Charity; the Children’s
Cancer and Leukaemia Group, Piam Brown Charitable Fund Southampton;
the German Ministry of Health and Education (BMBF 01GI9958/5); the
European Union Seventh Framework Programme (FP7 2007-2013) under
project European Network for Cancer Research in Children and Adoles-
cents (ENCCA) grant agreement no. 261743; the German Children’s
Cancer Foundation (Deutsche Kinderkrebsstiftung), Fo¨rdergemeinschaft
Kinderkrebszentrum Hamburg e.V.; the French Ministry of Health; the
French National Cancer Institute; the Swedish Childhood Cancer Foun-
dation; Wessex Medical Research; and Cancer Research UK.
HC-C and AR are co-first authors.
Conflict of interest: none.
Acknowledgments
d
The authors thank the participating families,
PNET4 committee, and all PNET4 investigators.
Int J Radiation Oncol Biol Phys, Vol. 92, No. 5, pp. 978
e
985, 2015
0360-3016/$ - see front matter 2015 Elsevier Inc. All rights reserved.
http://dx.doi.org/10.1016/j.ijrobp.2015.04.023RadiationOncology
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