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Conclusion
•
RT important; GTR important
•
RT dose-response relationship proven
•
Pattern of 1st relapse mainly local
•
M0: Local RT to 54-59.4 Gy standard today (age?)
•
CSI reserved for M+ disease
•
Role of Boost for residual disease
(i.e. 2 x 4 Gy)
?
•
In recurrences again surgery plus RT
(maybe even CSI
as risk for dissemination seems to be quite high)
•
Modern techniques beneficial
for volume reduction
and improved feasibility