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MAPK PATHWAY ALTERATIONS
ARE UNEVENLY
DISTRIBUTED ACROSS BRAIN
REGIONS
REPRESENTATION OF MAPK
PATHWAY WITH ABERRATIONS
Affecting 50-100% of Pilocytic
Astrocytomas
Oncogene Induced Senescence
Excessive MAPK activation induces
Irreversible cell cycle arrest by
p16
Ink4a
/Rb or the p14
Arf
/p53
pathway.
Primary cultured pilocytic
astrocytoma cells display clear
SA-β-
Gal
activity indicative cell cycle
arrest