576-577 / 1708
QoL in adult survivors of childhood brain tumours
A population study
& A Conceptual Model
HRQL deficits in adult survivors. EJC(2009) 2552–2561.
Boman et al Case Control Study
•
Persistent deficits: cognition, sensory functions,
mobility, self-care & overall health
•
Worse for IGCT, oligos / other glioma, medulloblastoma.
•
Mild to moderate disability ~ 60%
•
Education and Independence::
•
need for remedial training ,
•
lower educational status
•
greater reliance on governmental subsidies in adulthood
•
support as parents
Multifactorial late effects model: EJPN (2015) 1e21;
Tallen et al: Systematic Literature Review
•
Tumour-related
•
“Surgical neurotoxicity”
•
Radiotherapy
•
Neurocognitive and behavioural impairments
•
Endocrine deficits
•
Neuropathies
•
Neurovascular injury
•
Sensory deficits
•
Consequences of chemotherapy
•
Encephalopathy and neurocognitive decline
•
Premature Ageing
•
Second Tumours