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EuroNet-PHL-C1 study design

TG-2

I

E

A/B, II

E

A,

II B, III A

TG-3

II

E

B, III

E

A/B,

III B, IV A/B

2x OEPA

2x OEPA

2x COPP or 2x COPDAC

4x COPP or 4x COPDAC

weeks

1

5

9

13

17

21

R

R

RT

Radiotherapy

inadequate

response

adequate

response

no RT

Radiotherapy

RT

Radiotherapy

inadequate

response

adequate

response

no RT

Radiotherapy

Radiotherapy TG – 2 / 3; intermediate and high risk

Staging

With PET

Response

assessment

With PET