774 / 1708
3-D vs. IMRT in RMS (COG D9803)
IMRT
3-D CRT
Median follow-up
4.2 years
5.7 years
5-year local failure rate
15%
18%
Advantages of IMRT
1. PTV receiving 95% of prescribed dose greater for IMRT
2. Lower mean dose to brainstem with IMRT
3. Both treatment have similar target dose heterogeneity
Lin C et al. Int J Radiat Oncol Biol Phys 2012; 82:1764-70