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1975

N= 29 Children > 35 Gy

N= 15 Children < 25 Gy

15,000 normal Children

RetardaDon in children < 6 years

during puberty

Vertebral bodies decreased in height

Disk spaces are narrowed

IrregulariDes of the corDcal end-plates

Asymmetric ossificaDon

RT Dose 44 Gy