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Radiobiology for OAR - NTCP
•
There are
mechanistic derived models
for predicting TCP (based on
probability of tumor stem cells lost during the treatment)
•
There are
not convincing mechanistic models
for describing all side effect
onset
Stem cells loss (dry mouth, myelopathy)
Abnormal cell growth (fibrosis, telangiectasia)
•
Likelihood of side effects onset is proportional to the administered dose
Using the probability density function of normal distribution (probit)
Using the probability density function of other statistical distribution (logit – Log
dose )