Conclusions
Physical optimisation
using quadratic cost functions to
penalize the dose deviations seems practical, but may be too
optimistic in meeting the clinical objective
Radiobiological optimisation
will become more trustworthy
by judicious use of more accurate dose-response models
Physico-biological optimisation
can generate plans that
are clinically recognized and fulfill the dose and dose-volume
constraints based on clinical practice, while outperforming
physically optimised plans
Special acknowledgements to Aswin Hoffmann who kindly provided many slides